RAF Typhoon jets have operated alongside French aircraft in a joint strike on an hidden munitions depot in Syrian territory employed by the IS group, per a report from the UK's MoD.
The location, identified by intelligence, was believed to be containing munitions and bombs, the statement said, and was situated in hills just above Palmyra in central Syria.
"Our aircraft used laser-guided Paveway IV weapons to hit a number of approach shafts leading to the facility... initial indications suggest the strike was effective," officials stated.
There was no evidence of any harm to civilians in the attack late on Saturday and each participating jet made a safe return, the defence officials confirmed.
The British jets were backed up by a Voyager aerial refuelling aircraft.
IS - also known as the so-called Islamic State - enforced extremist governance over large swathes of both Syria and Iraq until 2019.
"This strike demonstrates British leadership, and determination to stand shoulder to shoulder with allied nations, to stamp out any revival of IS and their harmful and extremist ideologies in the region," the British Defence Secretary John Healey said.
RAF aircraft have performed patrols over Syria to "forestall any efforts to regroup" of IS after its military defeat at the Baghuz confrontation in 2019, the authorities noted.
"I want to thank all the members of our armed forces involved in this strike for their expertise and their courage," the Defence Secretary said. "Including them were thousands of British troops deployed over Christmas and New Year. This operation, to remove dangerous terrorists who endanger our security, shows how British military are prepared to act, throughout the year, protecting the UK at home and influential overseas."
Last December, the US military executed what it termed a "major assault" against IS targets in the country, after an assault killed two US troops and a local interpreter in the Palmyra area.
The U.N. says IS still boasts roughly 5-7 thousand militants in Syria and Iraq.